Here’s a detailed post by Melinda Clayton from Indies Unlimited on stripping unwanted formatting from your Word document before submitting it to Kindle. Her directions apply to PC users. I use a Mac, and was able to format my books fairly easily following Mark Coker’s directions for Smashwords. In both cases, making sure you have a clean document is essential.
My InDesign experience is much more complicated. I’m close to submitting to Ingram and will see how it works. More on my crazy journey into InDesign for IngramSpark coming soon!